Study of restriction fragment length polymorphism in the cystatin C gene of elderly patients with dementia and aged Down's syndrome patients
Palsdottir, A.; Thorsteinsson, L.; Jonsdottir, S.; Arnason, A.; Snaedal, J.; Magnusson, T.; Snorrason, E.; Ingibergsdottir, R.; Abrahamson, M.; Olafsson, I.
Progress in Clinical and Biological Research 317: 235-239
1989
ISSN/ISBN: 0361-7742 PMID: 2574869 Document Number: 327296
Using a full length cystatin C cDNA probe and the Alu I restriction enzyme a total of 33 patients with senile dementia, Alzheimer type and 31 Down's syndrome patients have been investigated for the presence of the 630 bp Alu I restriction fragment length polymorphism in the cystatin C gene detected in Icelandic patients with hereditary cystatin C amyloid angiopathy. Results showed that all the patients had normal cystatin C fragment length of 600 bp.