Effect of taktivin on diuresis and tubular cardiotrast secretion in the kidney
Arion, V.I.; Berkhin, E.B.; Galiuteva, G.I.; Ul'ianov, G.P.; Sanina, I.V.
Biulleten' Eksperimental'noi Biologii i Meditsiny 107(3): 264-266
1989
ISSN/ISBN: 0365-9615 PMID: 2713458 Document Number: 327292
The effect of a new immunomodulator taktivin (7-20 micrograms/kg subcutaneously, for 6 days) on the diuresis and tubular transport of cardiotrast (diodrast) was studied on rats. taktivin was shown to increase the tubular transport of the xenobiotic without significant changes in glomerular filtration and renal excretion of water, sodium, potassium, uric acid and creatinine. Possible mechanism of taktivin's action on the tubular transport of xenobiotics is discussed.