Primary hyperparathyroidism and peptic ulcer
Gasparoni, P.; Caroli, A.; Sardeo, G.; Maschio, S.; Lo Giudice, C.; Fioretti, D.
Minerva Medica 80(12): 1327-1330
1989
ISSN/ISBN: 0026-4806 PMID: 2622574 Document Number: 326887
The prevalence of peptic ulcer disease was retrospectively analysed in 35 patients affected by primary hyperparathyroidism consecutively observed from 1977 through 1987. Eight of the examined patients (22.8%) had peptic ulcer (7 duodenal and 1 gastric ulcer), that in five cases (14%) represented the first clinical manifestation of the endocrine disease. A Zollinger-Ellison syndrome was demonstrated in three cases (8.5% of the total series, 37% of the patients with ulcer). There was no difference in calcium, gastrin and parathormone serum level between patients with and without ulcer, excluding patients with Zollinger-Ellison syndrome. These data confirm the high prevalence of peptic ulcer disease in hyperparathyroidism, but the mechanism causing this association remains to be elucidated.