Role of manganese in mucopolysaccharide metabolism
Leach, R.M.
Federation Proceedings 30(3): 991-994
1971
ISSN/ISBN: 0014-9446 PMID: 4252533 Document Number: 32560
Chemical analysis and histological studies show skeletal and postural defects caused by Mn deficiency to be associated with a reduction in tissue mucopolysaccharide content. Chondroitin sulfate is the mucopolysaccharide most affected by Mn deficiency. The observations may be explained by a generalized requirement for Mn2+ by many glycosyltransferase enzymes including those needed for chondroitin sulfate synthesis.