Quantifying manganese in lymphocytes to assess manganese nutritional status
Matsuda, A.; Kimura, M.; Kataoka, M.; Ohkuma, S.; Sato, M.; Itokawa, Y.
Clinical Chemistry 35(9): 1939-1941
1989
ISSN/ISBN: 0009-9147 PMID: 2776320 Document Number: 336615
To clarify whether manganese nutritional status is better reflected by the manganese concentration in lymphocytes or in whole blood, we injected manganese solutions intravenously into manganese-deficient rats and determined manganese concentrations in lymphocytes, whole blood, and various tissues. The manganese concentrations in lymphocytes and tissues, but not in whole blood, were significantly less in manganese-deficient rats than in normal rats. These low values could be prevented by intravenous injection of mangenese in a dose-dependent manner. These results suggest that, for assessment of mangenese nutritional status, measurement of manganese in lymphocytes is better than that in whole blood.