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Mitochondrial inclusions in renal epithelial cells of magnesium-deficient rats

Sarkar, K.

Journal of Submicroscopic Cytology and Pathology 20(1): 179-184

1988

ISSN/ISBN: 1122-9497
PMID: 2836050
Document Number: 325202
In rats with prolonged magnesium deficiency, paracrystalline inclusions in mitochondria were found frequently in the epithelial cells of the thick ascending limb of Henle, especially in the region of the upper medulla. The inclusions presented a variegated appearance. Some were filamentous aggregates, many had alternating dark and light bands, and others were elongated rectangular densities. They were not found in tubules with calcific deposits where the cells showed degenerative changes. This suggested that the inclusions were probably due to altered cell metabolism and not products of cell degeneration.

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