Responses of human B-cells to recombinant lymphokines
Gallagher, G.; Taylor, N.; Willdridge, J.; Christie, J.F.; Stimson, W.H.
Developments in Biological Standardization 69: 65-73
1988
ISSN/ISBN: 0301-5149 PMID: 3265680 Document Number: 324785
The effects of recombinant or purified cytokines on the growth and differentiation of human B-cells from a variety of sources were evaluated. The results suggest that IL-1, BCGF and BSF-2 have either "growth-factor" or "differentiation-factor" activity and that only IL-2 has both these functions. In addition, evidence is presented that the two forms of human IL-1 affect B-cell growth differently. Finally, the separation of human normal and leukaemic B-cells into subsets defined by their buoyant cell density, is described.
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