Pharmacological analysis of the participation of serotonin in the central mechanisms of the development of a neurogenic stomach lesion in the rat
Bul'on, V.V.
Farmakologiia i Toksikologiia 51(1): 34-37
1988
ISSN/ISBN: 0014-8318 PMID: 3258827 Document Number: 324753
The involvement of the central serotoninergic structures in the development of neurogenic gastric lesions caused by a 3-hour electrostimulation of immobilized rats was shown. D,L-5-hydroxytryptophan exerted no protective effect on the formation of destructive lesions of the gastric mucosa. Deseril and BC-15 (Pizotifen, Sandomigran) significantly reduced the formation of hemorrhagic erosions and prevented a decrease of serotonin and noradrenaline levels and creatine phosphate content in the brain tissue.