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Randomized double-blind study of flunarizine versus placebo in patients with chronic cerebrovascular disorders

Agnoli, A.; Manna, V.; Martucci, N.; Fioravanti, M.; Ferromilone, F.; Cananzi, A.; D'Andrea, G.; De Rosa, A.; Vizioli, R.; Sinforiani, E.

International Journal of Clinical Pharmacology Research 8(3): 189-197

1988

ISSN/ISBN: 0251-1649
PMID: 3042644
Document Number: 324217
Chronic cerebrovascular disorders (CCVD), as defined by the 1980 Ad Hoc Committee in Paris, constitute both clinically and pathogenetically an extremely complex entity, characterized by a protean symptom pattern. The effects of a daily dose of 10 mg flunarizine orally on CCVD have been evaluated with a neuropsychological methodology during a three-month treatment period in a randomized double-blind study compared with a placebo. The results confirmed the effectiveness of the drug in the improvement of neurological, amnesic, attentive and behavioural symptoms, without evident side-effects even after a long-term treatment.

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