Studies on mutarotation and anomeric conversion of dihydroqinghaosu
Wang, Z.S.; Cao, X.L.
Yao Xue Xue Bao 23(8): 610-615
1988
ISSN/ISBN: 0513-4870 PMID: 3254042 Document Number: 324069
Polarimetry and HPLC were used to study the solution of dihydroqinghaosu in polar solvents such as methanol and ethanol. The mutarotation and conversion of anomers of dihydroqinghaosu were observed and a few kinetic parameters were measured. It was found that the equilibrium constant and the initial forward rate constant of anomeric conversion of dihydroqinghasu (.beta. to .alpha.) depended upon the solvents, temperature and other factors. Hydrochloric acid can be used as a catalyst for the conversion reaction. A mechanism of the mutarotation and anomeric conversion of dihydroqinghaosu, a kind of hemiacetal, was proposed.