Red cell enzyme deficiencies: a review

Stiene, E.A.

American Journal of Medical Technology 38(11): 454-461


ISSN/ISBN: 0002-9335
PMID: 4404285
Document Number: 3236
The red cell maintains its functional state for approximately 120 days through a highly ordered enzymatic mechanism. If a red cell develops a defective mechanism, it has no means for repairs and little or no means of compensation. The purpose of this paper is threefold: (1) to review the basic chemistry involved in the mechanism of energy production in the red cell (anaerobic glycolysis); (2) to discuss the two most common deficiencies in this system, namely glucose-6-phosphate dehydrogenase deficiency and pyruvate kinase deficiency and their consequences; and (3) to present a brief survey of other enzymes and enzyme deficiencies found in the mature red cell.

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Red cell enzyme deficiencies: a review