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Comparative activity of cefotetan against plasmid-encoded aminoglycoside-resistant enterobacteria strains

Gomez-Lus, R.; Otal, I.; Gomez-Lus, M.L.; Sarraseca, C.; Castillo, J.; Gil, J.; Rubio, M.C.

Chemioterapia International Journal of the Mediterranean Society of ChemoTherapy 7(4): 267-270

1988

ISSN/ISBN: 0392-906X
PMID: 3180307
Document Number: 323492
304 strains of R-plasmid harbouring enterobacteria resistant to aminoglycosides were studied for their susceptibilities to a range of antibiotics, including cefotetan. Cefotetan and latamoxef were the most active of the four cephamycins tested and all were stable to the beta-lactamases produced by these strains. No new beta-lactamases (SHV-2, CTX-1, TEM-4, CAZ-1) were found in these strains capable of hydrolysing third generation cephalosporins. The activity of cefotetan against these multi-resistant, beta-lactamase producing strains may be of clinical value.

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