Importance of analogs of LHRH in the treatment of bone metastasis of cancer of the prostate in 1988
Bessoule, O.; Le Loët, X.; Deshayes, P.
Revue du Rhumatisme et des Maladies Osteo-Articulaires 55(11): 885-887
1988
ISSN/ISBN: 0035-2659 PMID: 3060974 Document Number: 322718
LHRH analogous drugs cause a marked decrease of the testicular secretion, similar to that noted after pulpectomy or estrogen therapy. The experience acquired enables to consider LHRH analogous drugs as alternative in the first intention treatment of the bone metastases prostatic cancer if pulpectomy is refused or if estrogen therapy indicated because of its cardiovascular risks. It is not yet whether the systematic and long-term adjunction of an anti-androgen to LHRH analogous drugs, really increases its efficacy. In the late stage of bone metastases, when the effects of pulpectomy estrogen therapy have ended, LHRH analogous drugs only result in when the tumor process is still hormone-dependent.