Changes in factor VIII proteins after cardiopulmonary bypass in man suggest endothelial damage
Jones, D.K.; Luddington, R.; Higenbottam, T.W.; Scott, J.; Cavarocchi, N.; Reardon, D.; Calvin, J.; Wallwork, J.
Thrombosis and Haemostasis 60(2): 199-204
1988
ISSN/ISBN: 0340-6245 PMID: 2975406 Document Number: 322495
16 patients undergoing coronary artery bypass grafting using cardiopulmonary bypass (CPB) had blood samples taken at various times before, during and up to 1 week after surgery for estimation of beta-thromboglobulin (BTG), alpha-1-antichymotrypsin (ACT), factor VIII procoagulant protein (VIII:C), von Willebrand factor antigen (vWF:Ag) and ristocetin co-factor (vWF:RiCoF). vWF:Ag and vWF:RiCoF rose during and following surgery in a different manner to ACT. At 1 week there was a significantly disproportionate rise in vWF:Ag compared to vWF:RiCoF which suggested a degree of pulmonary endothelial damage. Prostacyclin, which was administered to 8 of the patients during CPB, reduced platelet activation as measured by a reduction in the release of BTG and also attenuated the consumption of VIII:C. It had no effect on pulmonary endothelial damage as measured by the ratio of vWF:Ag to vWF:RiCoF.