On the release of prednisone from oil in water microemulsions
Gasco, M.R.; Gallarate, M.; Pattarino, F.
Il Farmaco; Edizione Pratica 43(10): 325-330
1988
ISSN/ISBN: 0430-0912 PMID: 3234536 Document Number: 321651
The reservoir effect of an oil in water microemulsion was examined by permeability studies. Prednisone was used as a lipophilic drug. Three o/w microemulsions containing a fixed amount of lecithin as surfactant and different percentages of cosurfactant (butanol) were employed. The permeability constants obtained from microemulsions were 4-5 times lower than the ones obtained from solutions. The amount of alcohol influenced the diffusion rate of the drug.
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