Dysphoric symptoms in chronic alcoholics and the effect of carbamazepine (Tegretol)
Carlsson, C.; Pettersson, L.
Internationale Zeitschrift für Klinische Pharmakologie Therapie und Toxikologie. International Journal of Clinical Pharmacology Therapy and Toxicology 5(4): 403-405
1972
ISSN/ISBN: 0020-9392 PMID: 4558246 Document Number: 3213
In a double blind trial against placebo carbamazepine (Tegretol®) decreased dysphoric symptoms (=irritability) in chronic alcoholics from 3.71 points to 1.95 according to the rating scale used. Even if the difference is not statistically significant (0.30>P>0.20) the findings may confirm a clinical impression that carbamazepine is of value in the treatment of dysphoric symptoms in chronic alcoholics. There was a certain correlation between such symptoms and signs of brain damage in alcoholic patients, and this might have some relation to the effect.
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