Killing of virus-induced thymic lymphoma cells obtained from primary and early transfers by activated macrophages
Boteach, D.; Gallily, R.
Israel Journal of Medical Sciences 24(9-10): 518-521
1988
ISSN/ISBN: 0021-2180 PMID: 3264552 Document Number: 320787
Primary radiation leukemia virus-induced thymic lymphomas were susceptible to both stasis and lysis mediated by LPS-activated macrophages. During short in vitro cultivation the X-irradiation-induced lymphoma (PIR-2) cells were killed to the same extent (up to 99%) by LPS-activated macrophages as the RadLV lymphoma cells at effector:target ratios of 10:1 and 1:1. Since RadLV is not present in PIR-2 lymphoma cells, its presence is not required for susceptibility of the lymphoma cells to macrophage-mediated killing. Our data also disprove the assumption that artifacts of long-term cultivation in vitro are responsible for tumor susceptibility to cytostasis and cytolysis mediated by activated macrophages.