Viscosity of subretinal fluid--relationship with composition and clinical findings
Matsuda, K.
Nippon Ganka Gakkai Zasshi 92(4): 611-618
1988
ISSN/ISBN: 0029-0203 PMID: 3407562 Document Number: 320029
The viscosity of subretinal fluid was measured with a cone-plate viscometer. Subretinal fluid exhibited non-Newtonian behavior, showing pseudoplastic viscosity, i.e. the viscosity was higher at low shear rates. The distribution of viscosity of subretinal fluids was higher than in serum and equal to or higher than that of liquefied vitreous fluid. Subretinal fluid and liquefied vitreous fluid are pseudoplastic fluids in contrast to serum which is a Newtonina fluid, i.e. viscosity is the same at all shear rates. There was a significant correlation between the viscosity and hyaluronate contents of subrentinal fluid. On the other hand, there was no correlation between the viscosity and protein and glycopeptide contents. Hylauronidase treatment decreased the visocity of subretinal fluid. These results revealed that hyaluronate caused viscosity in subretinal fluid as well as vitreous humor. The relationship between the clinical findings of various kinds of retinal detachments and the viscosity of subretinal fluid was evaluated by students t-test and multivariate analysis containing quantification I and multiple regression using the computerized statistics program package SPSS. There was a tendency for aphakia or total detachment to correlate with lower subretinal fluid visocity.