Polyamine metabolism and interconversion in NIH 3T3 and ras-transfected NIH 3T3 cells
Pakala, R.; Kreisel, M.; Bachrach, U.
Cancer Research 48(12): 3336-3340
1988
ISSN/ISBN: 0008-5472 PMID: 3285993 Document Number: 319737
The effect of transfection of NIH 3T3 cells by the human ras (c-Ha-ras-1) oncogene on uptake, interconversion, and excretion of polyamines was studied. Uptake and interconversion of spermidine were higher in the ras-transfected cells. Acetylpolyamines were excreted into the medium by the ras-transfected cells, whereas they were retained by NIH 3T3 cells. In addition to acetylpolyamines, some unknown polyamine conjugates occurred in the ras-transfected cells.