Aspirin-induced gastroduodenal injury and its prevention by prostaglandins
Cohen, M.M.
Postgraduate Medical Journal 64 Suppl. 1: 12-14
1988
ISSN/ISBN: 0032-5473 PMID: 3047723 Document Number: 319660
It appears likely that aspirin injury and thus bleeding is due to both inhibition of the mucosal synthesis of protective endogenous prostanoids and to a local irritant effect. This injury can be abolished in humans by acid-inhibitory doses of prostaglandins and can probably be ameliorated by 'cytoprotective' doses. It has yet to be shown that the gastropathy seen in patients taking long-term aspirin-like drugs can be prevented or treated by prostaglandins. The clinical relevance of such protection has not yet been established.