Ribonucleases and deoxyribonucleases in pancreatic cancer: clinical value and pathophysiological interrelationships
Del Favero, G.; Basso, D.; Fabris, C.; Angonese, C.; Meani, A.; Vianello, D.; Pedrazzoli, S.; Dodi, G.; Naccarato, R.
International Journal of Pancreatology Official Journal of the International Association of Pancreatology 3(Suppl 1): S107-S112
1988
ISSN/ISBN: 0169-4197 PMID: 3209863 Document Number: 319564
In this study we evaluated some pathophysiological aspects of pancreatic and liver ribonucleases and alkaline deoxyribonuclease and their clinical usefulness in diagnosing pancreatic cancer. Pancreatic RNase was found to be a sensitive index of pancreatic malignancy; however it was not specific in distinguishing pancreatic malignancy from chronic pancreatitis or other pathologies. Liver RNase and alkaline DNase did not provide better results than pancreatic RNase. These three enzymes were found to be age-dependent and related to each other. Therefore serum nucleases are not useful for clinical purposes since they are influenced, at least in part, by different non-specific factors.