Effect of Argiope lobata venom and its components on L[3H) glutamate binding with locust muscle membranes
Usmanov, P.B.; Tonkikh, A.K.; Shadyeva, N.G.; Sadykov, A.A.; Tashmukhamedov, B.A.
Ukrainskii Biokhimicheskii Zhurnal 60(3): 78-81
1988
ISSN/ISBN: 0201-8470 PMID: 2901152 Document Number: 318159
The Argiope lobata venom is shown to block synaptic potential at locust neuromuscular junctions and inhibit the high-affinity sodium independent L[3H]glutamate binding site in locust muscle membranes. The data obtained due to fractionation of venom evidence that it contains components which block synaptic potential and inhibit the binding of L[3H]glutamate (5 kDa and more) as well as components which block synaptic potential but do not inhibit the binding of L[3H]glutamate less than 5 kDa. These observations indicate that spider venom contains at least two components with different mechanism of action.