Effect of long-term use of Norplant implants on haemostatic function
Singh, K.; Viegas, O.A.; Koh, S.C.; Ratnam, S.S.
Contraception 45(3): 203-219
1992
ISSN/ISBN: 0010-7824 PMID: 1380904 Document Number: 317574
This study describes the effects of NorplantR on haemostatic function after 5 years of use in 97 women. There was a decrease in vitamin-K dependent Factors II, V, VII and reduction in fibrinolytic activity at 2 and 4 years of use. Increased platelet numbers and accelerated platelet aggregation were found throughout the 5 years of NorplantR use, whilst raised alpha2-Macroglobulin (a2-M) and antithrombin III (ATIII) antigen level were observed for up to 4 years of use. Prolonged NorplantR use does not appear to activate the coagulation system and does not enhance a state of hypercoagulation.
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