Morphological signs of the blocking effect of immunoglobulins and immune complexes in breast cancer before and after radiotherapy
Dorosevich, A.E.
Arkhiv Patologii 50(4): 11-16
1988
ISSN/ISBN: 0004-1955 PMID: 3408365 Document Number: 316369
Parenchyma of radiation-treated (48.0%) and untreated (47.9%) fibroadenomas, dysplasias, breast cancer (in 57.1%, 55.6% and 47.9% of cases, respectively) are shown to contain deposits of immune complexes (IC) and immunoglobulins (Ig) of the main classes. This may be an underlying cause of the blocked interaction between epithelial cells and lymphocytes supported by a significant reduction in the specific lymphocyte density observed for parenchyma of IC-positive fibroadenoma and dysplasia, breast cancer periphery occurring before radiation therapy. Poor long-term outcomes of IC-positive breast cancer irrespective of radiation treatment allow the author to refer IC and Ig deposits to criteria of unfavorable prognosis as well as indicators of breast cancer cells radioresistance.