Effects of prolonged administration of flunarizine in rats
De Romanis, F.; Sopranzi, N.
La Clinica Terapeutica 125(4): 291-294
1988
ISSN/ISBN: 0009-9074 PMID: 2974365 Document Number: 315685
In this paper we have studied the rat under chronic treatment with flunarizine oral. For a six week period we have recorded, once a week, weight, rectal temperature, tail-flick time and general activity in a one-arm radial maze. Following a one-week drug-free period, surface EEG were recorded from treated animals. The findings were: 1) no change was observed in weight, rectal temperature and tail-flick time, 2) the treated rats when in a one-arm radial maze showed signs of sedation and grooming. The EEG (surface) recordings showed a slowing activity which agreed well with the signs of sedation and the behaviour showed in the one-arm radial maze.