Vitamin D deficiency and its correction in children with terminal stage of chronic kidney failure
Tsybysheva, A.K.; Burkov, I.V.; Blazhevich, N.V.; Pereverzeva, O.G.; Spirichev, V.B.
Voprosy Meditsinskoi Khimii 34(4): 112-117
1988
ISSN/ISBN: 0042-8809 PMID: 3264096 Document Number: 315218
Content of vitamin D, evaluated by the level of 25(OH]D2 (calcidiol), was decreased in 68 patients with chronic kidney insufficiency, among which 16 patients required hemodialysis, 52 patients exhibited a terminal step of chronic kidney insufficiency and were treated with programme-assigned hemodialysis. Content of the vitamin was more distinctly decreased in the patients, kidney insufficiency of which developed simultaneously with congenital and hereditary kidney diseases. Phosphorus-calcium metabolism in the patients was corrected using both high doses of vitamin D2 (20,000 IU) and I alpha-hydroxycholecalciferol (oxidevite) combined with small doses of vitamin D2 (2,000 IU). The later procedure was more effective. After the treatment calcidiol was normalized within a month and maintained within a year at a level close to normal values. Blood calcium was normalized within 2 months, while normalization of parathormone and thyrocalcitonine occurred within a year. After treatment with vitamin D2 at a dose of 20,000 IU distinct hypercalcediolemia as observed in all the patients within 4 months. In 25% of the patients we noted hypercalcemia, which might lead to metastatic calcification.