Immunologically mediated induction of hyperlipoproteinemia
Osipov, S.G.; Titov, V.N.; Rumiantsev, A.G.
Biulleten' Eksperimental'noi Biologii i Meditsiny 106(8): 151-153
1988
ISSN/ISBN: 0365-9615 PMID: 2970869 Document Number: 314967
The relationship of immune and metabolic processes, particularly, those of lipid metabolism, was studied in mice with diet induced hyperlipoproteinemia, leukemia-related immune deficiency and in situ formation of antigen-antibody complexes after immunostimulation. A marked immunosuppression was observed in mice on a high-cholesterol diet, but when immune complex formation was induced after antigen injection, a high level of nonesterified cholesterol and low density lipoproteins was obtained, whereas an increase in high density lipoproteins in leukemic mice was observed. It is concluded that there exists a certain mechanism of immunologically mediated induction of hyperlipoproteinemia, which leads to the inhibition of immune response by immunoregulatory lipoproteins under conditions of antigen stimulation.