Biotransformation of 4-oxa-5-exo- (N-methylcarbamoyloxy) -tricyclo-[5.2.1.0-2, 6endo] dec-8-en-3one in the rat
Neidlein, R.; Deigner, H.P.
Arzneimittel-Forschung 38(2): 260-266
1988
ISSN/ISBN: 0004-4172 PMID: 3370074 Document Number: 314540
The metabolism of the analgesic compound 4-oxa-5-exo-(N-methylcarbamoyloxy)-tricyclo-[5.2.1.0-2. 6endo]dec-8-en-3one (Lu 253) was investigated after oral application in male Wistar rats. From urine, faeces, bile, and plasma epoxidized, rearranged, and N-desmethylated metabolites were isolated. The main reaction was the epoxidation of the double bond. The structure of most of the biotransformation products was proved by synthetic compounds.