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Structural basis for antiviral activity of flavonoids-naturally occurring compounds

Wleklik, M.; Luczak, M.; Panasiak, W.; Kobus, M.; Lammer-Zarawska, E.

Acta Virologica 32(6): 522-525

1988

ISSN/ISBN: 0001-723X
PMID: 2906224
Document Number: 314333
The effect of different substituents of quercetin and luteolin on the ability to inhibit the herpes simplex virus (HSV-1) replication in RK-13 cells was studied. It seems that parent compounds with free hydroxyl groups at C-5, C-7, C-3', C-4' and additionally at C-3 have the highest activity. Substitution of those groups caused decrease of or completely abolished the antiviral activity of the tested compounds.

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