Diversity of rotavirus strains infecting pediatric patients in New Delhi, India
Chatterjee, B.; Husain, M.; Kavita; Seth, P.; Broor, S.
Journal of Tropical Pediatrics 42(4): 207-210
1996
ISSN/ISBN: 0142-6338 PMID: 8816032 DOI: 10.1093/tropej/42.4.207Document Number: 313834
Polyacrylamide Gel Electrophoresis (PAGE) of rotavirus can provide information on variation in rotavirus strain prevalent in the community. In the present study 157 samples were collected from children below 5 years of age presenting with acute diarrhoea from May to December, 1990 at Safdarjung Hospital, New Delhi. Seventy-one (45 per cent) of these stool samples were positive for rotavirus by ELISA. Sixty-seven samples showed discernible RNA pattern of group A rotavirus by PAGE. It was found that there were seven electropherotypes co-circulating in this 8-month period. Majority of the strains had a IIC pattern, but IIA, IID, IIE, IIG, IE, and IB electropherotype patterns were also seen. The simultaneous co-circulation of multiple group A strains in the community may lead to extensive genomic variation in rotavirus strains.