Top Abstract Purchase Related
Home
>
Node
>
Subnode

Pharmacokinetics of ceftazidime in the cerebrospinal fluid

Decazes, J.M.

Presse Medicale 17(37): 1914-1916

1988

ISSN/ISBN: 0755-4982
PMID: 2973584
Document Number: 313158
A compound potentially effective in the treatment of meningitis should reach high concentrations in CSF. In animal experimental models, ceftazidime levels of 5-25 micrograms/ml were demonstrated during administration of doses generating serum levels similar to those achieved in humans. Human studies later confirmed CSF levels of 5-10 micrograms/ml in patients with meningitis. Ceftazidime CSF kinetic properties are adequate for use of this compound in patients with meningitis due to susceptible organisms.

Document emailed within 1 workday
Secure & encrypted payments

Tagami, T. 1970: Disc electrophoretic analysis of cerebrospinal fluid proteins in the disturbances of optic nerve. I. Comparison of cerebrospinal fluid at various sites in the cerebrospinal axis. With special reference to the cerebrospinal fluid in the chiasmatic cistern Nippon Ganka Gakkai Zasshi 74(9): 1129-1135
Imagawa, K.; Kawasaki, M.; Toda, I.; Hayashi, M.; Asai, A.; Nomura, T. 1982: Pharmacokinetics of ACNU in cerebrospinal fluid Gan to Kagaku Ryoho. Cancer and ChemoTherapy 9(9): 1543-1548
Moreau, X.; Le Quay, L.; Granry, J.C.; Boishardy, N.; Delhumeau, A. 1993: Pharmacokinetics of paracetamol in the cerebrospinal fluid in the elderly Therapie 48(4): 393-396
Vistelle, R.; Lamiable, D.; Zinsou, M.; Leon, A.; Wiczewski, M. 1992: Toloxatone pharmacokinetics in the plasma and cerebrospinal fluid of the rabbit Journal of Pharmacy and Pharmacology 44(2): 124-126
Drost, R.H.; Ionescu, T.I.; Taverne, R.H.; van Lingen, G.; van Rossum, J.M.; Maes, R.A. 1988: Pharmacokinetics of morphine in cerebrospinal fluid and plasma after epidural administration in man Arzneimittel-Forschung 38(11): 1632-1634
Koch, A.; Federspil, P.; Hartmetz, G. 1985: Metronidazole pharmacokinetics in perilymph, aqueous humor and cerebrospinal fluid Laryngologie Rhinologie Otologie 64(12): 649-651
Ramu, A.; Fusner, J.E.; Blaschke, T.; Glaubiger, D.L. 1978: Probenecid inhibition of methotrexate-cerebrospinal fluid pharmacokinetics in dogs Cancer Treatment Reports 62(10): 1465-1470
Chabot, G.G.; Rivard, G.E.; Momparler, R.L. 1983: Plasma and cerebrospinal fluid pharmacokinetics of 5-Aza-2'-deoxycytidine in rabbits and dogs Cancer Research 43(2): 592-597
Kerr, I.G.; Zimm, S.; Collins, J.M.; O'Neill, D.; Poplack, D.G. 1984: Effect of intravenous dose and schedule on cerebrospinal fluid pharmacokinetics of 5-fluorouracil in the monkey Cancer Research 44(11): 4929-4932
Reed, M.D.; Rekate, H.L.; Aronoff, S.C.; Myers, C.M.; Blumer, J.L. 1983: Single-dose plasma and cerebrospinal fluid pharmacokinetics of ceftriaxone in infants and children Clinical Pharmacy 2(6): 558-563
Scherber, A.; Henker, J. 1982: Chemotherapy of purulent meningitis in childhood. I. Pharmacokinetics of antibacterial drugs in the cerebrospinal fluid Kinderarztliche Praxis 50(4): 182-186
Chin, T.; Fong, I.W.; Vandenbroucke, A. 1990: Pharmacokinetics of fluconazole in serum and cerebrospinal fluid in a patient with AIDS and cryptococcal meningitis PharmacoTherapy 10(4): 305-307
Abelson, H.T.; Ensminger, W.; Rosowsky, A.; Uren, J. 1978: Comparative effects of citrovorum factor and carboxypeptidase G1 on cerebrospinal fluid-methotrexate pharmacokinetics Cancer Treatment Reports 62(10): 1549-1552
Okura, K.; Haruta, T.; Kobayashi, Y. 1984: Pharmacokinetics in the cerebrospinal fluid after simultaneous administration of latamoxef and ampicillin to rabbits with staphylococcal meningitis Japanese Journal of Antibiotics 37(9): 1637-1646
Muchi, H.; Ijima, H.; Karube, T. 1985: The treatment of childhood acute lymphoblastic leukemia based on the pharmacokinetics of methotrexate in serum and cerebrospinal fluid Nihon Ketsueki Gakkai Zasshi: Journal of Japan Haematological Society 48(6): 1397-1408
Chang, P.-J.; Sung, Y.-H.; Tsai, Y.-C.; Fang, S.-Y.; Chen, H.-H. 2002: Continuous cerebrospinal fluid drainage using a lumbar subarachnoid catheter for cerebrospinal fluid rhinorrhea after functional endoscopic sinus surgery Acta Anaesthesiologica Sinica 40(2): 97-99
Schulz, D.; Rothenhöfer, C. 1979: Anatomical structures, physiology and pathophysiology of cerebrospinal fluid metabolism; a review for an understanding of cerebrospinal fluid findings Fortschritte der Medizin 97(40): 1814-1820
Döbler, K.; Nolte, H. 1990: Do elevated blood and cerebrospinal fluid glucose levels and other factors modify the density of cerebrospinal fluid and the spread of isobaric spinal anesthesia? Regional-Anaesthesie 13(4): 101-107
Kanoh, Y.; Ohara, T.; Akahoshi, T. 2011: Acute Inflammatory Biomarkers in Cerebrospinal Fluid as Indicators of Blood Cerebrospinal Fluid Barrier Damage in Japanese Subjects with Infectious Meningitis Clinical Laboratory 57(1-2): 37-46
Oberascher, G. 1988: Cerebrospinal otorrhea--cerebrospinal rhinorrhea. the Salzburg concept of cerebrospinal fluid diagnosis Laryngologie Rhinologie Otologie 67(8): 375-381