Comparative toxicity of synthetic and natural glycerin
Hine, C.H.; Anderson, H.H.; Moon, H.D.; Dunlap, M.K.; Morse, M.S.
A.M.A. Archives of Industrial Hygiene and Occupational Medicine 7(4): 282-291
1953
ISSN/ISBN: 0096-6703 PMID: 13039584 Document Number: 3125
The chief pharmacologic effect of either glycerin was stimulation of the central nervous system. The chief alteration in anatomic structure following intragastric administration of either glycerin was congestion of the pylorus, small intestine, lungs, and kidneys. Chronic toxicity studies showed that after rats had been fed 20% natural or synthetic glycerin for one year there were no significant differences between experimental and control subjects. After rats had been fed 5 or 10% natural or synthetic glycerin for a period of two years, there were no significant differences as regards per cent of weight gain, results of urinalysis and hemoglobin determinations, or percentage of mortality. There was no evidence of organ stress at any level of either glycerin, and there were no gross or microscopic lesions attributable to the glycerin feeding. Statistical comparison of the mean weekly food consumption of the various groups indicated a slightly greater intake by male rats receiving 5 and 10% natural glycerin, in comparison with males receiving the same levels of synthetic glycerin. Sensitization tests on guinea pigs and skin and eye irritation studies on albino rabbits showed that no sensitization occurred and that no skin irritation appeared after 90 days of application. There was no measurable eye irritation. There were no toxicologic differences between the natural and the synthetic glycerin, so far as our studies could detect. Neither gave evidence of toxic effects.
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