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Cytogenetic study of Kaposi's sarcoma associated with acquired immunodeficiency syndrome

Saikevych, I.A.; Mayer, M.; White, R.L.; Ho, R.C.

Archives of Pathology and Laboratory Medicine 112(8): 825-828

1988

ISSN/ISBN: 0003-9985
PMID: 3395219
Document Number: 312284
We performed cytogenetic studies on direct preparations and short-term cultures from Kaposi's sarcoma cells obtained from malignant pericardial effusion. The patient, a 46-year-old man with human immunodeficiency virus infection, initially presented with metastatic Kaposi's sarcoma. Despite therapy, his tumor proved aggressive, and the patient died of widespread pulmonary involvement nine months after diagnosis. Cytogenetic analysis revealed a predominant karyotype of 48,X,-Y, t(2;7)(q32;q36), +der(5)t(5;15)(q?15;Q?15), -7, +del(7)(p15), +del(7)(p15), +der(8)t(8;D or G)(q24; p11.2), del(10)(p13), dup(12)(q24), t(18;20)(w21;q13). This case is described in relation to other published cytogenetic studies of this tumor.

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