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MSS18, a yeast nuclear gene involved in the splicing of intron aI5 beta of the mitochondrial cox1 transcript

Séraphin, B.; Simon, M.; Faye, G.

EMBO Journal 7(5): 1455-1464

1988

ISSN/ISBN: 0261-4189
PMID: 2842150
Document Number: 310670
We have isolated and characterized a nuclear gene, MSS18, which is implicated in the splicing of intron aI5.beta. of the mitochondrial cox1 transcript (subunit 1 of the cytochrome c oxidase). Northern blotting and S1 nuclease protection experiments as well as the analysis of mitochondrial point revertants suggest that mss18 mutations block (perhaps indirectly) the cleavage of the 5' exon-intron junction of aI5.beta. Mitochondrial point revertants also indicate that up to 13 bases of the aI5.beta. exon sequence, upstream of the 5' splice site of aI5.beta., are involved in vivo in the splicing of this intron. The implications of this result on the splicing of group I introns are discussed.

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