Formation of DNA adduct 8-hydroxy-2'-deoxyguanosine induced by man-made mineral fibres
Leanderson, P.; Söderkvist, P.; Tagesson, C.; Axelson, O.
Iarc Scientific Publications 89: 422-424
1988
ISSN/ISBN: 0300-5038 PMID: 3198230 Document Number: 310549
Two man-made mineral fibres, rockwool and glasswool, were found to mediate hydroxylation of deoxyguanosine and calf thymus DNA to form the DNA adduct 8-hydroxy-2'-deoxyguanosine. The modification of the nucleoside is probably mediated by hydroxyl radicals and may play a role in fibre-induced carcinogenesis.
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