IgA glomerulonephritis and pregnancy
Packham, D.K.; North, R.A.; Fairley, K.F.; Whitworth, J.A.; Kincaid-Smith, P.
Clinical Nephrology 30(1): 15-21
1988
ISSN/ISBN: 0301-0430 PMID: 3208456 Document Number: 310093
One hundred and sixteen pregnancies in 70 women with a biopsy-proven diagnosis of IgA glomerulonephritis have been analyzed. Thirty percent (35%) of the fetuses died, 22% (26) were premature and 44% (52) were full term. Maternal renal function declined during pregnancy in 26% (30) and in 2% (2) this was irreversible post-partum. Hypertension developed in 52% (61) of the pregnancies and in 13% (15) this was irreversible. Increased proteinuria was recorded in 62% (74) of the pregnancies. Fetal loss in pregnancies taking place after biopsy diagnosis was lower (16%) than those in which biopsy was performed either during or following the pregnancy (36%).