Passive immune complex glomerulonephritis in mice: models for various lesions found in human disease. I. High avidity complexes and mesangiopathic glomerulonephritis
Germuth, F.G.; Rodriguez, E.; Lorelle, C.A.; Trump, E.I.; Milano, L.; Wise, O.
Laboratory Investigation; a Journal of Technical Methods and Pathology 41(4): 360-365
1979
ISSN/ISBN: 0023-6837 PMID: 158674 Document Number: 149205
I.v. injection of mice with soluble complexes of highly avid rabbit antibody to egg albumin, prepared by dissolution of equivalence precipitates in large quantities of antigen, resulted in purely mesangial localization of the complexes. When animals received 3 injections of complexes per day for 1 day, precipitates dissolved in 80 times the equivalence amount of antigen produced slight mesangial changes. When such complexes were injected for 2 or 3 days, outright mesangiopathic glomerulonephritis was observed in an increasing proportion of the animals. Equivalent amounts of antigen alone did not produce lesions.