A trial quantitative analysis or respiratory control system reproducibility through the use of variation coefficients of ventilatory parameters
Suenaga, N.; Hayashi, F.; Miyauchi, N.; Nishioka, Y.; Kitada, O.; Sugita, M.
Nihon Kyobu Shikkan Gakkai Zasshi 26(11): 1177-1181
1988
ISSN/ISBN: 0301-1542 PMID: 3249484 Document Number: 310018
The reproducibility of a respiratory control system was quantitatively evaluated using the coefficient of variation (CV) of ventilatory parameters (tidal volume; VT, total respiratory cycle; Ttot, minutes ventilation; .ovrhdot.V1) and end-tidal PCO2 (PETCO2) calculated from respective values measured for periods of 2 minutes. In healthy male subjects, mean .+-. SD values of CV of VT, Ttot and .ovrhdot.V1 were 12.5 .+-. 6.3, 13.1 .+-. 5.5 and 14.9 .+-. 3.7%, respectively. In the future, these values will be available for evaluating abnormalities in the reproducibility of ventilation as seen in hyperventilation syndrome. Isocapnic hypoxia reduced the CV of ventilatory parameters, indicating that reproducibility of the respiratory control system was enhanced by the hypoxic stimulus. The possible mechanisms for increasing the reproducibility of ventilatory parameters by hypoxic stimulus were discussed.