L-carnitine and rehabilitative respiratory physiokinesitherapy: metabolic and ventilatory response in chronic respiratory insufficiency
Dal Negro, R.; Pomari, G.; Zoccatelli, O.; Turco, P.
International Journal of Clinical Pharmacology Therapy and Toxicology 24(8): 453-456
1986
ISSN/ISBN: 0174-4879 PMID: 3759281 Document Number: 285348
Twelve subjects suffering from type A chronic respiratory insufficiency were admitted to a double blind, randomized, placebo-controlled trial. The aim of the trial was the evaluation of the effects of the oral administration of L-carnitine, 2 g twice daily for 15 days, on the metabolic and respiratory parameters, at the mild physical work load involved in rehabilitative respiratory physiokinesitherapy. As previously reported, treatment with L-carnitine prevents the metabolic acidosis and hyperventilation caused by physiokinesitherapy in patients with chronic respiratory insufficiency. In correlation with the metabolic role of L-carnitine, the results of this trial suggest that L-carnitine is an essential training-like metabolic factor, particularly when the physical performance is impaired by inadequate respiratory function.