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Thymidine kinase and disaccharidase activities in intestinal mucosa in health and disease

Mittal, S.K.; Lloyd, D.; Brown, G.; McNeish, A.S.

Indian Pediatrics 25(1): 51-55

1988

ISSN/ISBN: 0019-6061
PMID: 3146550
Document Number: 309458
Activities of thymidine kinase and disaccharidases (lactase, sucrase and maltase) were estimated in whole tissue homogenates of jejunal biopsies from 15 normal children, 4 with non-specific enteropathy (NSE) and 7 with subtotal villus atrophy (STVA) on routine histology. The disaccharidases were decreased in children with STVA (p < 0.01) and thymidine kinase was increased in children with NSE (p < 0.05) and STVA (p < 0.01). Comparison of thymidine kinase/lactase and thymidine kinase/sucrase ratios clearly delineated the damaged mucosa from normal mucosa.

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