Anemia of inflammation in dogs infected with Ehrlichia platys
Baker, D.C.; Gaunt, S.D.; Babin, S.S.
American Journal of Veterinary Research 49(7): 1014-1016
1988
ISSN/ISBN: 0002-9645 PMID: 3421524 Document Number: 309292
Ten adult male dogs were inoculated with Ehrlichia platys, and blood samples were collected throughout the infection to evaluate the hematologic changes with respect to serum biochemical analytes. All dogs developed a mild, normocytic, normochromic anemia by postinoculation day 7, with significantly (P less than 0.05) decreased serum iron concentration and total iron-binding capacity. Stainable bone marrow iron appeared normal or increased throughout the infection. By postinoculation day 31, the PCV was not significantly different from the pretreatment value. All dogs became hypergammaglobulinemic, leukopenic, hypoalbuminemic, and hypocalcemic during the infection. These findings were compatible with the syndrome of anemia of inflammation.