Effect of calcium ionophore A23187 and of leukotrienes B4 and C4 on the adherence of human mononuclear leukocytes
Mayer, M.
Biomedica Biochimica Acta 47(1): 83-87
1988
ISSN/ISBN: 0232-766X PMID: 2839164 Document Number: 307556
The adherence changes induced by the ionophore A23187 and by the leukotrienes, respectively, were investigated in 10 healthy persons. The calcium ionophore A23187 in concentrations of 200 nM, 1 microM and 5 microM induced inhibition of mononuclear leukocyte adherence in a concentration-dependent manner, the maximal adherence inhibition being proved with 5 microM ionophore. The leukotrienes did not significantly alter leukocyte adherence in the test system used. The results of this study suggest that the calcium ionophore A23187-induced leukocyte adherence inhibition may serve as a pharmacological model of the leukocyte adherence inhibition phenomenon, thus providing a useful tool for the investigation of the processes associated with some cellular membrane functions.