Studies on the teratogenic potential of sodium dehydroacetate in rats
Tanaka, S.; Kawashima, K.; Nakaura, S.; Djajalaksana, S.; Takanaka, A.
Eisei Shikenjo Hokoku. Bulletin of National Institute of Hygienic Sciences 1988(106): 54-61
1988
ISSN/ISBN: 0077-4715 PMID: 3250657 Document Number: 305555
Sodium dehydroacetate was given orally by stomach intubation to pregnant Wistar rats at the dose levels of 0, 25, 50 or 100 mg/kg during days 6 to 17 of gestation, and the effects of the compound on fetal development and postnatal growth of offspring were examined. In the two higher dose groups of 50 and 100 mg/kg, maternal body weight gains and food consumptions were suppressed. In the fetuses from both dose groups, considerable body weight loss, high incidence of skeletal variations and retardation of ossification were observed. Increase in fetal death was also observed in the highest dose group, which was considered to be due to marked retardations in intrauterine developments. However, there was no evidence of fetal malformations attributable to the treatment of sodium dehydroacetate, and the postnatal growth of the offspring was not retarded in any of the dose groups. It is conclude that sodium dehydroacetate has a retardant effect on fetal developments but not a teratogenic effect in the rat.