Immunopathogeny of pemphigus

Squiquera, L.; Anhalt, G.J.; Diaz, L.A.; Sampaio, S.A.; Rivitti, E.A.; Martins, C.R.; Cunha, P.R.; Lombardi, C.; Almeida, F.A.; Martins Castro, A.; Squiquera, L; Anhalt, G.J; Diaz, L.A; Sampaio, S.A; Rivitti, E.A; Martins, C.R; Cunha, P.R; Lombardi, C; Almeida, F.A; Martins Castro, A

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Immunopathogeny of pemphigus

Squiquera, L.; Anhalt, G.J.; Diaz, L.A.; Sampaio, S.A.; Rivitti, E.A.; Martins, C.R.; Cunha, P.R.; Lombardi, C.; Almeida, F.A.; Martins Castro, A.

Medicina Cutanea Ibero-Latino-Americana 16(5): 385-392

1988

ISSN/ISBN: 0210-5187

PMID: 3070194

Document Number: 305477

This article reviews recent concepts of pathogenetic mechanisms in pemphigus. We describe the pathogenic effect of the autoantibodies, the animal model for the disease and the ultrastructural alterations which follow the antibody-antigen interaction. The role of complement and protease systems in development of tissue injury are also discussed.