Urinary metabolism of dextromethorphan in man
Köppel, C.; Tenczer, J.; Ibe, K.
Arzneimittel-Forschung 37(11): 1304-1306
1987
ISSN/ISBN: 0004-4172 PMID: 3440042 Document Number: 305225
After an oral dose of 50 mg of (+)-3-methoxy-N-methylmorphinan (dextromethorphan) to volunteers, urinary metabolism was studied by gas chromatography/mass spectrometry. A total of 15 previously unknown metabolites and derivatives of dextromethorphan could be identified by mass spectrometric techniques. The main metabolic pathways were: O,N-demethylation, O,N-acetylation, hydroxylation of the phenyl ring and the saturated ring system with subsequent further oxidation.