Interaction of alcohol and methamphetamine with acute high dose administration to rats
Yamamura, T.; Hishida, S.; Hatake, K.; Taniguchi, T.; Sakaki, N.; Oouchi, H.; Tanaka, I.
Arukoru Kenkyu to Yakubutsu Izon 22(4): 286-299
1987
ISSN/ISBN: 0389-4118 PMID: 3449029 Document Number: 305124
The combined effects of acute administration of alcohol (Alc) with the sublethal dose of 2g/kg and methamphetamine (MAMP) with the lethal dose of 30 mg/kg were examined through observation of abnormal behavior, recording of locomotor activity and physiological changes with heart rate and rectal temperature in rats. They are also investigated by the endogenous assay following MAMP distribution in organs and a variation of intracerebral amine level changes. There exists a temporary antagonism at the initial period of dosage with a lasting stimulated effect, with which occurs a rebound phenomena at the latter time, for behavioral and physiological changes, after an acute coadministration of MAMP and Alc. Alc activates the transportation of MAMP into the internal organs to alleviate the reduction of intracerebral amines such as norepinephrine, dopamine and serotonin. It can be concluded that the dual complexed interaction of MAMP and Alc acts to reinforce synergically the stimulating effect MAMP rather than to antagonize it.