Computer programs for an algorithm for least-squares estimation of LD50
Zhong, Y.X.
Zhongguo Yao Li Xue Bao 8(2): 185-189
1987
ISSN/ISBN: 0253-9756 PMID: 2959011 Document Number: 304734
Suppose the relation of mortality rate p to log dose x is a distribution function F(.mu., .sigma., x) of N(.mu., .sigma.2). With PC-1500 computer using the data log dose x, number of animals n, and mortality rate p, it is found by Marquardt method that the expression .**GRAPHIC**. reaches the minimum on .mu. = .mu.0, .sigma. = .sigma.0. Consequently the log LD 50 = .mu.o is obtained. Examples using this algorithm are provided.
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