Antidepressant action of lithium in behavioral despair test
Eroğlu, L.; Hizal, A.
Polish Journal of Pharmacology and Pharmacy 39(6): 667-673
1987
ISSN/ISBN: 0301-0244 PMID: 2460846 Document Number: 304568
The effects of long term (30 days) lithium treatment of various doses on behavioral despair test and on serotonin metabolism in the hypothalamus, midbrain and striatum of rats were examined. Lithium at doses of 0.5, 2 and 5 mEq/kg significantly decreased the duration of immobility. In other words, lithium behaved as an antidepressant drug. Serotonin turnover increased only in the hypothalamus in response to 0.5 and 2 mEq/kg doses of lithium.