Detrimental effect of propylene glycol on natural killer cell and neutrophil function
Denning, D.W.; Webster, A.D.
Journal of Pharmacy and Pharmacology 39(3): 236-238
1987
ISSN/ISBN: 0022-3573 PMID: 2883293 Document Number: 303843
Propylene glycol (PG) in a concentration of 0.5-1.0% inhibits natural cytotoxicity and neutrophil chemiluminescence. This is the first reported effect of PG on defence mechanisms in man. PG is frequently used as a vehicle in high concentrations by the pharmaceutical industry and its would be wise to consider its potential immunosuppressive effects in the evaluation of drug formulations.
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