Hormone and lipid interrelations in young women with normal and disturbed balance of sex steroids
Shardin, S.A.; Barats, S.S.; Benediktov, I.I.
Terapevticheskii Arkhiv 59(11): 46-50
1987
ISSN/ISBN: 0040-3660 PMID: 3441864 Document Number: 303811
Altogether 121 patients with sclerocystic ovaries and 40 normal women aged 16 to 35 years were examined for excretion of estrogens, androgens and pregnandiol with urine and for the blood content of total cholesterol (TC), triglycerides (TG) and high density lipoprotein cholesterol (HDLC) followed by hyperlipoproteinemia (HLP) phenotyping. In the group of normal women, low production of estrogens and pregnandiol was coupled with a reduction in the content of HDLC and an increase in that of TG. In the patients, no relationship was established between the changes in the concentration of estrogens and pregnandiol and the lipid content. Meanwhile the androgen content, which was higher as compared with that in the normal women, correlated with the rise of the TG and TC level, accompanied by a noticeable subsidence of the HDLC level. As compared with the normal persons, the atherogenic types of HLP in the patients occurred 2.2 times as frequently. The data obtained indicate an important role of the primary imbalance of sex steroids in the development of dyslipoproteinemia in young women.